Influence of combined genotypes of RETN G 62 A with C - 180 G and G 299 A polymorphisms on colon cancer risk
نویسنده
چکیده
Understanding the biology and genetic alterations of adipocytokines, cell-signaling proteins secreted by adipose tissue, provides new insights into the pathogenesis and treatment of several diseases including cancer. In the present study, we investigated the role of RETN gene G62A variant in the pathophysiology of colon cancer. A group of 120 Saudi volunteers (60-colon cancer patients and 60 disease-free controls) within the same age range was studied. PCR-RELP technique was used to determine the single nucleotide polymorphism (SNP). The results were compared with the control group. Analysis of SNP+62 genotypes results showed 100% normal (GG) in both the patients and the controls. Heterozygous (GA) and homozygous (AA) genotypes were not detected in all the patients and the controls. The interesting result in this study is the combined effect of G62A SNP with RETN C-180G and G299A SNPs. The results showed a decrease risk of colon cancer reflecting the protective role of SNP G62A in the development of colon cancer. These results suggest that these variants in RETN gene and their interactions are strongly associated with the development of colon cancer. [Rowyda N. Al-Harithy and Ayat B. Al-Ghafari. Influence of combined genotypes of RETN G62A with C-180G and G299A polymorphisms on colon cancer risk. Cancer Biology 2014;4(2):79-86]. (ISSN: 2150-1041): (ISSN: 2150-105X (online). http://www.cancerbio.net. 10
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